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Home >> Antibodies >> CDw78

CDw78

Mouse Monoclonal Antibody [Clone DF1588]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified CDw78 Monoclonal Antibody (DF1588). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Leu21; Ba antigen; LO panBa

Positive Control

Raji and human peripheral blood lymphocytes. Human tonsil and lymph node.

Known Applications & Suggested Dilutions

Func., Flow Cyt, IF         More Details

Functional Studies (Order Ab without Azide)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human leucocytes

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

Not Known

Specificity & Comments

Reacts with a carbohydrate determinant, identified as CDw78 (Workshop V; Code CDw78.2). Epitope recognized by this MAb and Leu21 is the same. It is present on some immature and some peripheral blood B cells, and some B cell lines. Its expression is increased after B-cell activation in vitro. CDw78 is also found on tissue macrophages and on epithelial cells, but not on T cells, NK cells, monocytes, granulocytes and myeloid tissues. It appears that CDw78 is a determinant on a major histocompatibility complex (MHC) class II subpopulation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kikutani H et al. Expression and function of an early activation marker restricted to human B cells. J Immunol 1986, 136(11):4019-4026.
  2. Schlossman SF et al. Leukocyte Typing V, p604-606, Oxford University Press, Oxford, 1995.
  3. Slack JL et al. Molecular characterization of the pan-B cell antigen CDw78 as a MHC class II molecule by direct expression cloning of the transcription factor CIITA. Int Immunol 1995, 7(7):1087-1092.
  4. Knapp W et al. Leukocyte Typing IV, p122, p155-162 and p165-174, Oxford University Press, Oxford, 1989.
  5. Rasmussen AM et al. CDw78--a determinant on a major histocompatibility complex class II subpopulation that can be induced to associate with the cytoskeleton. Eur J Immunol 1997, 27(12):3206-3213.

Bioinformatics

NBT00353