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Home >> Antibodies >> CD71 / Transferrin Receptor (TFRC) (Extracellular Domain)

CD71 / Transferrin Receptor (TFRC) (Extracellular Domain)

Mouse Monoclonal Antibody [Clone TFRC/1839]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Placenta stained with CD71 Mouse Monoclonal Antibody (TFRC/1839).

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SDS-PAGE Analysis Purified CD71 Mouse Monoclonal Antibody (TFRC/1839). Confirmation of Integrity and Purity of Antibody

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Analysis of Protein Array containing >19,000 full-length human proteins using CD71 Mouse Monoclonal Antibody (TFRC/1839)

Product Details

Synonyms

Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

Positive Control

Jurkat, HeLa, MCF-7 or K562 cells. Human placenta or Bone Marrow.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant extracellular fragment (around aa 94-212) of human TFRC protein (exact sequence is proprietary)

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

85-95kDa (monomer); 190kDa (dimer)

Specificity & Comments

It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Oudermans et al. Cancer, 1986; 58:1252.
  2. K. Moolenaar et al. Cancer research 50,1102-1106, 1990.

Bioinformatics

  •  Entrez Gene ID: 7037
  •  Gene Symbol: TFRC
  •  SwissProt: P02786
  •  Chromosome Location: 3q29
  •  Unigene: 529618
NBT01839