Formalin-fixed, paraffin-embedded human Placenta stained with CD71 Monoclonal Antibody (TFRC/1818).
Formalin-fixed, paraffin-embedded human Bone Marrow stained with CD71 Mouse Monoclonal Antibody (TFRC/1818).
SDS-PAGE Analysis Purified CD71 Mouse Monoclonal Antibody (TFRC/1818).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.