2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> CD71 / Transferrin Receptor (TFRC)

CD71 / Transferrin Receptor (TFRC)

Mouse Monoclonal Antibody [Clone 66IG10]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Flow Cytometry of human CD71 on K562 cells. Black: cells alone; Grey: Isotype Control; Green: AF488-labeled CD71 Mouse Monoclonal Antibody (66IG10).

img

Flow Cytometric Analysis of Jurkat cells. CD71 Mouse Monoclonal Antibody (66IG10) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

img

SDS-PAGE Analysis Purified CD71 Mouse Monoclonal Antibody (66IG10). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

Positive Control

CCRF-CEM, Jurkat or K-562. Human placenta or breast carcinoma.

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF         More Details

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human thymocytes (T-cells)

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

85-95kDa (monomer); 190kDa (dimer)

Specificity & Comments

It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. K. Moolenaar et al. Cancer research 50,1102-1106, 1990.
  2. Van de Rijna M, Geurts van Kessel AHM, Kroezen V, van Agthoven AJ, Verstijnen K, Terhorst C, Hilgers J: Cytogenet Cell Genet 1983;36:525-531.
  3. Oudermans et al. Cancer, 1986; 58:1252.

Bioinformatics

  •  Entrez Gene ID: 7037
  •  Gene Symbol: TFRC
  •  SwissProt: P02786
  •  Chromosome Location: 3q29
  •  Unigene: 529618
NBT00871