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Home >> Antibodies >> CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker)

CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker)

Mouse Monoclonal Antibody [Clone BU69]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00

Product Details

Synonyms

CD27 ligand (CD27L); CD27LG; Ki24; Surface antigen CD70; Tumor necrosis factor (ligand) superfamily, member 7 (TNFSF7)

Positive Control

Raji cells. Lymph node or tonsil.

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF, IP, IHC-Fr         More Details

ELISA (For coating, order Ab without BSA)
Inhibits T cell proliferation induced by dendritic cells (Order Ab without Azide)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunoprecipitation (1-2ug/500ug protein lysate)
Immunohistochemistry (Frozen) (1-2ug/ml for 30 minutes at RT)
Optimal dilution for a specific application should be determined.

Immunogen

Human WM-1 (Waldenstrom s macroglobulinemia) cell line

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

30kDa

Specificity & Comments

It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown toinhibit T cell proliferation induced by dendritic cells.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.
  2. R.Q. Hintzen, et al, (1994) J Immunol 152: 1762-1773.
  3. M.R. Bowman, et al, (1994) J Immunol 152: 1756-1761.
  4. K. Agematsu, et al, (1995) J Immunol 154: 3627-3635.

Bioinformatics

  •  Entrez Gene ID: 970
  •  Gene Symbol: CD70
  •  SwissProt: P32970
  •  Chromosome Location: 19p13
  •  Unigene: 501497, 715224
NBT00187