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Home >> Antibodies >> CD7 (T-Cell Leukemia Marker)

CD7 (T-Cell Leukemia Marker)

Mouse Monoclonal Antibody [Clone B-F12]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified CD7 Mouse Monoclonal Antibody (Clone B-F12). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

GP40; Leu9; p41; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41

Positive Control

Jurkat, HUT-78, Molt-4, CEM cells or human peripheral blood lymphocytes. Lymph node and tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Chronic Lymphoid Leukemia cells (CLL)

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

40kDa

Specificity & Comments

Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Miwa H, et al biological characteristics of CD7(+) acute leukemia. Leuk Lymphoma. 1996;21:239-44.
  2. Knapp W et al. eds. Leukocyte typing IV, p341, Oxford University Press, Oxford, 1989.
  3. Rabinowich H, et al. J. Immunol. 1994 153(8):3504-3513.
  4. Emara M, et al. A human suppressor T-cell factor that inhibits T-cell replication by interaction with the IgM-Fc receptor (CD7). Hum Immunol. 1989;25(2):87-102.
  5. Saxena A, et al. Biologic and clinical significance of CD7 expression in acute myeloid leukemia. Am J Hematol. 1998;58(4):278-84.

Bioinformatics

  •  Entrez Gene ID: 924
  •  Gene Symbol: CD7
  •  SwissProt: P09564
  •  Chromosome Location: 17q25.3
  •  Unigene: 186820
NBT00310