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Home >> Antibodies >> CD64 / Fc gamma RI

CD64 / Fc gamma RI

Mouse Monoclonal Antibody [Clone FCGR1A/7498]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified CD64 Mouse Monoclonal Antibody (FCGR1A/7498). Confirmation of Integrity and Purity of Antibody.

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IHC analysis of formalin-fixed, paraffin-embedded human tonsil. Membrane stained using FCGR1A/7498 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

CD64; CD64A; CD64b; CD64c; Fc fragment of IgG, high affinity Ia, receptor (CD64); FCGR1; FCGR1A; FCGR1B; FCGR1C; FcRI; FcRIB; FCRIC; High affinity immunoglobulin gamma Fc receptor IB; IGFR1; IGFRB; IGFRC

Positive Control

Human tonsil or lymph node.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human FCGR1A protein (exact sequence is proprietary)

Cellular Localization

Cell Membrane

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG

Mol. Weight of Antigen

43kDa

Specificity & Comments

Three different classes of IgG Fc receptors have been described: Fc γ RI (CD64), Fc γ RII (CD32) and Fc γ RIII (CD16). The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN-γ stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will coimmunoprecipitate with CD64 subsequent to receptor cross linking.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1mg/ml.

Key References

  1. Townsend, S.M., et al. 2003. Infect. Immun. 71: 5871-5880.

Bioinformatics

  •  Entrez Gene ID: 2209
  •  Gene Symbol: FCG10.1A
  •  SwissProt: P12314
  •  Chromosome Location: 1q21.2
  •  Unigene: 534956 & 77424