Flow cytometry of U937 cells stained with CD64 monoclonal antibody (10.1) (red) or isotype control (gray) followed by goat anti-mouse CF640R (red).
Flow cytometry of monocyte gated PBMCs stained with CD64 monoclonal antibody (10.1) (red) or isotype control (gray) followed by goat anti-mouse CF640R (red).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Three different classes of IgG Fc receptors have been described: Fc stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will co-immunoprecipitate with CD64 subsequent to receptor cross linking.