Formalin-fixed, paraffin-embedded Tonsil stained with CD6 Monoclonal Antibody (SPM547)
Immunofluorescence staining of MOLT-4 cells using CD6 Monoclonal Antibody (SPM547) followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei are stained with Reddot.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.