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Home >> Antibodies >> CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker)

Recombinant Rabbit Monoclonal Antibody [Clone NCAM1/2217R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CD56 Rabbit Recombinant Monoclonal Antibody (NCAM1/2217R).

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SDS-PAGE Analysis Purified CD56 Rabbit Recombinant Monoclonal Antibody (NCAM1/2217R). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

NCAM, Leu-19, NKH1, MSK39, NCAM120, NCAM140, NCAM180, Neural Cell Adhesion Molecule

Positive Control

Colon or Small Intestine.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human NCAM1 (CD56) protein

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

180, 145 and 125kDa

Specificity & Comments

This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Hilkens et al., Int J Cancer. 1984 34:197-206.
  2. Kibbelaar et al. Eur. J. Cancer 1991 27:431-435.

Bioinformatics

  •  Entrez Gene ID: 4684
  •  Gene Symbol: NCAM1
  •  SwissProt: P13591, P13592
  •  Chromosome Location: 11q23.1
  •  Unigene: 503878
NBT02217