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Home >> Antibodies >> CD5 (Mantle Cell Lymphoma Marker)

CD5 (Mantle Cell Lymphoma Marker)

Mouse Monoclonal Antibody [Clone CRIS-1]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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FCM staining of human PBMCs using CD5 Monoclonal Antibody (CRIS-1).

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SDS-PAGE Analysis Purified CD5 Monoclonal Antibody (CRIS-1). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5

Positive Control

293T, Ramos or MOLT-4 cells. Tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF, Func., IP         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Functional Studies (Order Ab without BSA & Azide)
Immunoprecipitation (0.5-1ug/500ug protein lysate)
Optimal dilution for a specific application should be determined.

Immunogen

Stimulated human leukocytes

Cellular Localization

Cell surface

Species Reactivity

Human. Rhesus Monkey.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

67kDa

Specificity & Comments

Recognizes a 67kDa transmembrane protein, which is identified as CD5 (HLDA I; WS Code T 29HLDA III; WS Code T 530). The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Arrizabalaga P, Mirapeix E, Darnell A, Torras A, Revert L: Cellular immunity analysis using monoclonal antibodies in human glomerulonephritis. Nephron. 1989;53(1):41-9.
  2. Alberola-Ila J, Places L, Cantrell DA, Vives J, Lozano F: Intracellular events involved in CD5-induced human T cell activation and proliferation. J Immunol. 1992;148(5):1287-93.
  3. Leukocyte Typing III., McMichael A. J. et al. (Eds.), Oxford University Press (1987).
  4. Guarne A, Bravo J, Calvo J, Lozano F, Vives J, Fita I: Conformation of the hypervariable region L3 without the key proline residue. Protein Sci. 1996;5(1):167-9.

Bioinformatics

  •  Entrez Gene ID: 921
  •  Gene Symbol: CD5
  •  SwissProt: P06127
  •  Chromosome Location: 11q12.2
  •  Unigene: 58685
NBT00176