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Home >> Antibodies >> CD45RB (Leucocyte Marker)

CD45RB (Leucocyte Marker)

Mouse Monoclonal Antibody [Clone BRA-11; same as BRA-11G]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

429.00

Formulation

Purified Ab Conjugated to PE

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab Conjugated to PE

Price (USD)

429.00

Product Details

Synonyms

B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein

Positive Control

Ramos, U-698 or GA-10 cells. Tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry: 5ul per test per one million cells (or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)Optimal dilution for a specific application should be determined.

Immunogen

Non-T, non-B CALLA positive ALL cell line REH (Leucocyte Workshop IV and V)

Cellular Localization

Cell surface and cytoplasmic

Species Reactivity

Human. Does not react with Rat or Rhesus Monkey.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

180-220kDa

Specificity & Comments

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

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Key References

  1. Sutherland et.al Int. Immunol., 14(8): 953 - 962 (August 1, 2002)
  2. Sedlak et al. Neoplasma 1989: 643, 1989.
  3. Lim et.al Int. Immunol., 18(2):291-300 (2006)

Bioinformatics

  •  Entrez Gene ID: 5788
  •  Gene Symbol: PTPRC
  •  SwissProt: P08575
  •  Chromosome Location: 1q31.3
  •  Unigene: 654514
NBT00174