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Home >> Antibodies >> CD45RB (Leucocyte Marker)

CD45RB (Leucocyte Marker)

Mouse Monoclonal Antibody [Clone BRA-11; same as BRA-11G]

Catalog #


0.5 ml at 100ug/ml

Price (USD)



Purified Ab Conjugated to CF488

Catalog No


0.5 ml at 100ug/ml


Purified Ab Conjugated to CF488

Price (USD)


Product Details


B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein

Positive Control

Ramos, U-698 or GA-10 cells. Tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry: 5ul per test per one million cells (or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)Optimal dilution for a specific application should be determined.


Non-T, non-B CALLA positive ALL cell line REH (Leucocyte Workshop IV and V)

Cellular Localization

Cell surface and cytoplasmic

Species Reactivity

Human. Does not react with Rat or Rhesus Monkey.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen


Specificity & Comments

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Related Products

Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Key References

  1. Sutherland et.al Int. Immunol., 14(8): 953 - 962 (August 1, 2002)
  2. Sedlak et al. Neoplasma 1989: 643, 1989.
  3. Lim et.al Int. Immunol., 18(2):291-300 (2006)


  •  Entrez Gene ID: 5788
  •  Gene Symbol: PTPRC
  •  SwissProt: P08575
  •  Chromosome Location: 1q31.3
  •  Unigene: 654514