Formalin-fixed, paraffin-embedded human Tonsil stained with CD45RB Mouse Monoclonal Antibody (BRA-11).
Western Blot Analysis of human Raji cell lysate using CD45RB Mouse Monoclonal Antibody (BRA-11).
SDS-PAGE Analysis Purified CD45RB Mouse Monoclonal Antibody (BRA-11). Confirmation of Integrity and Purity of Antibody.
Flow Cytometric Analysis of PFA-fixed Raji cells using CD45RB Mouse Monoclonal Antibody (BRA-11) followed by Goat anti- Mouse- IgG-CF488 (Blue); Isotype Control (Red).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin.