Formalin-fixed, paraffin-embedded human Tonsil stained with CD45 Mouse Recombinant Monoclonal Antibody (rPTPRC/1460).
Flow Cytometric Analysis of paraformaldehyde-fixed Raji cells using CD45 Mouse Recombinant Monoclonal Antibody (rPTPRC/1460) followed by Goat anti- Mouse- IgG-CF488 (Blue); Isotype Control (Red).
SDS-PAGE Analysis Purified CD45 Mouse Recombinant Monoclonal Antibody (rPTPRC/1460). Confirmation of Integrity and Purity of Antibody
Western Blot Analysis of human spleen tissue lysates using CD45 Mouse Recombinant Monoclonal Antibody (rPTPRC/1460)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.