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Home >> Antibodies >> CD40, Mouse

CD40, Mouse

Rat Monoclonal Antibody [Clone FGK45.5]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00

Product Details

Synonyms

B cell surface antigen CD40, CD40 type II isoform, p50, Bp50, CD40L receptor, CDW40, TRAP, IMD3, IGM, Tnfrsf5, HIGM1, GP39, T-BAM

Positive Control

MPBMC's. Spleen, Thymus or Lymph Node.

Known Applications & Suggested Dilutions

Func., Flow Cyt, IF         More Details

Functional Studies (Order Antibody without BSA & Azide)
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Purified recombinant Mouse CD40 fusion protein

Cellular Localization

Cell Surface

Species Reactivity

Mouse. Does not react with Human.

Host / Ig Isotype

Rat / IgG2a, kappa

Mol. Weight of Antigen

48kDa

Specificity & Comments

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus C. Bartholdy, et al. J. Immunol. 178 1662 (2007)

Bioinformatics

  •  Entrez Gene ID: 21939
  •  SwissProt: P27512
  •  Chromosome Location: 2 H3; 2 85.38 cM (Mouse)
NBT02005