Formalin-fixed, paraffin-embedded human Hodgkin’s Lymphoma stained with CD40 Mouse Monoclonal Antibody (C40/1605).
Formalin-fixed, paraffin-embedded human Spleen stained with CD40 Mouse Monoclonal Antibody (C40/1605).
Formalin-fixed, paraffin-embedded human Tonsil stained with CD40 Mouse Monoclonal Antibody (C40/1605).
SDS-PAGE Analysis Purified CD40 Mouse Monoclonal Antibody (C40/1605). Confirmation of Integrity and Purity of Antibody.
Flow Cytometric Analysis of U2OS cells using CD40 Mouse Monoclonal Antibody (C40/1605) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs.