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Home >> Antibodies >> CD4 (T-Helper/Inducer Cell Marker)

CD4 (T-Helper/Inducer Cell Marker)

Mouse Monoclonal Antibody [Clone C4/206]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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SDS-PAGE Analysis Purified CD4 Mouse Monoclonal Antibody (C4/206). Confirmation of Integrity and Purity of Antibody.

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Flow cytometry analysis of lymphocyte-gated PBMCs unstained (gray) or stained with CF488A-labeled CD4 mouse monoclonal antibody (C4/206)(green)

Product Details

Synonyms

L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; p55; T cell antigen T4/LEU3; T cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Positive Control

Human peripheral blood mononuclear cells (PBMCs), CCRF-CEM or HL-60. Lymph node or tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, ELISA         More Details

Flow Cytometry (0.5-2ug/million cells)
ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CD4 protein

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

55kDa

Specificity & Comments

Recognizes a protein of 55kDa, identified as CD4. CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Janeway, C.A., Jr. 1992. The T cell receptor as a multicomponent signaling machine: CD4/CD8 co-receptors and CD45 in T cell activation. Annu. Rev. Immunol. 10: 645-674.
  2. Arthos, J., et al. 1989. Identification of the residues in human CD4 critical for the binding of HIV. Cell 57: 469-481.

Bioinformatics

  •  Entrez Gene ID: 920
  •  Gene Symbol: CD4
  •  SwissProt: P01730
  •  Chromosome Location: 12p13.31
  •  Unigene: 631659
NBT00206