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Home >> Antibodies >> CD37 (Peripheral Mature B-Cell Marker)

CD37 (Peripheral Mature B-Cell Marker)

Mouse Monoclonal Antibody [Clone IPO-24]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Flow Cytometric staining of PHA stimulated PBMC. Green isotype control; Red CD37 Mouse Monoclonal Antibody (IPO24). Goat anti-Mouse PE was used as secondary antibody

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SDS-PAGE Analysis Purified CD37 Mouse Monoclonal Antibody (IPO24). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Cell differentiation antigen 37; GP52 40; Tetraspanin-26; Tspan-26; TSPAN26

Positive Control

Daudi, Raji, Namalva, Ramos cells and human lymphocytes. Human tonsil and lymph node.

Known Applications & Suggested Dilutions

Func., Flow Cyt, IF         More Details

Functional Studies (Order Ab without Azide)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Spleen cells of a patient with hairy cell leukemia

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

33-55kDa

Specificity & Comments

Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V; Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin'' lymphoma (B-NHL).

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Schlossman SF et al. eds. Leukocyte Typing V, p556-559, Oxford University Press, Oxford, 1995.
  2. Sidorenko SP et al. Monoclonal antibodies of IPO series against B cell differentiation antigens in leukemia and lymphoma immunophenotyping Neoplasma 1992;39(1):3-9.
  3. Angelisova P et al. Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins. Immunogenetics 1994;39(4):249-256.
  4. Sidorenko SP et al. Monoclonal antibodies of the IPO series in studying and diagnosing malignant lymphoproliferative diseases. Gematol Transfuziol 1990, 35(4):19-22
  5. Maecker HT et al. The tetraspanin superfamily: molecular facilitators. FASEB J 1997,11(6):428-442

Bioinformatics

  •  Entrez Gene ID: 951
  •  Gene Symbol: CD37
  •  SwissProt: P11049
  •  Chromosome Location: 19q13.3
  •  Unigene: 166556
NBT00170