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Home >> Antibodies >> CD35 / CR1 (Follicular Dendritic Cell Marker)

CD35 / CR1 (Follicular Dendritic Cell Marker)

Mouse Monoclonal Antibody [Clone CR1/802]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Tonsil stained with CD35 Mouse Monoclonal Antibody (CR1/802).

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Formalin-fixed, paraffin-embedded human Tonsil stained with CD35 Mouse Monoclonal Antibody (CR1/802).

Product Details

Synonyms

C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, KN, Knops blood group antigen

Positive Control

Follicular dendritic cells (FDC) in tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CR1 protein

Cellular Localization

Cell surface

Species Reactivity

Human. Baboon. Monkey.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

210-220kDa

Specificity & Comments

Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb does not block CR1 activity. It is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein.Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Ahearn, J.M. et al. 1989. Adv. Immunol. 46: 183-219.

Bioinformatics

  •  Entrez Gene ID: 1378
  •  Gene Symbol: CR1
  •  SwissProt: P17927
  •  Chromosome Location: 1q32.2
  •  Unigene: 334019
NBT00802