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Home >> Antibodies >> CD31 / PECAM-1 (Endothelial Cell Marker)

CD31 / PECAM-1 (Endothelial Cell Marker)

Mouse Monoclonal Antibody [Clone JC/70A]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

429.00

Formulation

Purified Ab conjugated to PE

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab conjugated to PE

Price (USD)

429.00
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Flow Cytometric Analysis of Jurkat cells using PE conjugated CD31 Mouse Monoclonal Antibody (JC/70A) Isotype Control (Red).

Product Details

Synonyms

EndoCAM; PECA1; Platelet Endothelial Cell Adhesion Molecule 1; GPIIA'

Positive Control

Jurkat, CCRF-CEM or K-562 cells. Tonsil, Angiosarcoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100 for 30 minutes at RT)
Optimal dilution for a specific application should be determined.

Immunogen

Membrane preparation of a spleen from a patient with hairy cell leukemia

Cellular Localization

Cell surface and cytoplasmic

Species Reactivity

Human. Cynomolgus Monkey. Rabbit. Does not react with Rat or Pig.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

~100kDa (endothelium) and ~130kDa (platelets)'

Specificity & Comments

CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.

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Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Key References

  1. Gratzinger D et. al. Am J Clin Pathol 131:264-278 (2009).

Bioinformatics

  •  Entrez Gene ID: 5175
  •  Gene Symbol: PECAM1
  •  SwissProt: P16284
  •  Chromosome Location: 17q23.3
  •  Unigene: 376675, 514412
NBT00639