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Home >> Antibodies >> CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker)

CD30 / TNFRSF8 (Hodgkin & Reed-Sternberg Cell Marker)

Mouse Monoclonal Antibody [Clone SPM121]

Catalog #

Size

0.1 ml
0.5 ml

Price (USD)

199.00
429

Formulation

Culture Supernatant
Culture Supernatant

Catalog No

Size

0.1 ml
0.5 ml

Formulation

Culture Supernatant
Culture Supernatant

Price (USD)

199.00
429
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Formalin-fixed, paraffin-embedded human Hodgkin's Lymphoma stained with CD30 Monoclonal Antibody (SPM121).

Product Details

Synonyms

CD30L receptor, Cytokine receptor CD30, Ki-1 antigen, Lymphocyte activation antigen CD30, Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)

Positive Control

Hodgkin's lymphoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1:50-1:100 for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 7.5-8.5, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Co cell line established from a patient with Hodgkin's disease of T-cell lineage

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

105-120kDa

Specificity & Comments

Recognizes a single chain glycoprotein of 105/120kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. In Hodgkin's disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).

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Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format.

Key References

  1. Schwarting R, Gerdes J, Durkop H, Falini B, Pileri S, Stein H. Ber-H2: A new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood 1989;74:1678-89.

Bioinformatics

  •  Entrez Gene ID: 943
  •  Gene Symbol: TNFRSF8
  •  SwissProt: P28908
  •  Chromosome Location: 1p36.22
  •  Unigene: 1314
NBT00772