2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> CD284 (Toll-Like Receptor 4)

CD284 (Toll-Like Receptor 4)

Mouse Monoclonal Antibody [Clone TLR4/230]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

SDS-PAGE Analysis Purified CD284 Mouse Monoclonal Antibody (TLR4/230). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

ARMD10; CD284; hToll; TLR4; TOLL; Toll Endotoxin Hyporesponsiveness; Toll-like receptor 4

Positive Control

HeLa, PC12, human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil; placenta and adrenal.

Known Applications & Suggested Dilutions

Func.         More Details

Functional Studies (Order Ab without Azide)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human TLR4 protein

Cellular Localization

Cell Surface

Species Reactivity

Human. Monkey. Pig. Dog. Rat. Guinea Pig.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

95-120kDa

Specificity & Comments

This MAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Wei, X.Q., et al. 2008. Clin. Invest. Med. 31: E123-E130.

Bioinformatics

  •  Entrez Gene ID: 7099
  •  Gene Symbol: TLR4
  •  SwissProt: O00206
  •  Chromosome Location: 9q33.1
  •  Unigene: 174312
NBT00230