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Home >> Antibodies >> CD282 (Toll-Like Receptor 2)

CD282 (Toll-Like Receptor 2)

Mouse Monoclonal Antibody [Clone TLR2/221]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified CD282 Mouse Monoclonal antibody (TLR2/221). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

CD282; Toll-like receptor 2 (TLR2); Toll/interleukin-1 receptor-like protein 4 (TIL4)

Positive Control

Normal human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil.

Known Applications & Suggested Dilutions

Func.         More Details

Functional Studies (Order Ab without Azide)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human TLR2 protein.

Cellular Localization

Cell Surface

Species Reactivity

Human. Monkey. Dog.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

90kDa

Specificity & Comments

This MAb reacts with human Toll-like receptor 2 (TLR2). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW, Carroll JD, Espevik T, Ingalls RR, Radolf JD, Golenbock DT. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem. 1999 Nov 19;274(47):33419-25.

Bioinformatics

  •  Entrez Gene ID: 7097
  •  Gene Symbol: TLR2
  •  SwissProt: O60603
  •  Chromosome Location: 4q32
  •  Unigene: 519033
NBT00221