Formalin-fixed, paraffin-embedded human Tonsil stained with CD21 / CR2 Mouse Monoclonal Antibody (CR2/1953).
Formalin-fixed, paraffin-embedded human Follicular Dendritic Cell Sarcoma stained with CD21 / CR2 Mouse Monoclonal Antibody (CR2/1953).
SDS-PAGE Analysis Purified CD21 / CR2 Mouse Monoclonal Antibody (CR2/1953). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using CD21 Mouse Monoclonal Antibody (CR2/1953)
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2) / CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.