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Home >> Antibodies >> CD209 / DC-SIGN (Pathogen Receptor on Dendritic Cells)

CD209 / DC-SIGN (Pathogen Receptor on Dendritic Cells)

Recombinant Mouse Monoclonal Antibody [Clone rC209/1781]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CD209 Mouse Monoclonal Antibody (rC209/1781).

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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CD209 Mouse Monoclonal Antibody (rC209/1781).

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SDS-PAGE Analysis Purified CD209 Mouse Monoclonal Antibody (rC209/1781). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

CD209; CDSIGN; CIRE; CLEC4L; DC-SIGN; DC-SIGN1; DCSIGN; Dendritic cell-specific ICAM-3 Grabbing Non-integrin 1; HIV GP120 Binding Protein; SIGN-R1; SIGNR5

Positive Control

THP-1 or HeLa cells (IF/FACS). Human liver or spleen lysate (WB). Human small intestine (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA Buffer, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human CD209 protein fragment (exact sequence is proprietary)

Cellular Localization

Cell surface and secreted

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

45kDa

Specificity & Comments

DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Steinman, R.M. 2000. DC-SIGN: A guide to some mysteries of Dendritic cells. Cell 100: 491-494.

Bioinformatics

  •  Entrez Gene ID: 30835
  •  Gene Symbol: CD209
  •  SwissProt: Q9NNX6
  •  Chromosome Location: 19p13
  •  Unigene: 278694
NBT03190