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Home >> Antibodies >> CD2 / Lymphocyte Function Antigen 2 (LFA-2)

CD2 / Lymphocyte Function Antigen 2 (LFA-2)

Mouse Monoclonal Antibody [Clone UMCD2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified CD2 Mouse Monoclonal Antibody (UMCD2). Confirmation of Integrity and Purity of Antibody.

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Western Blot Analysis of Jurkat Cell lysate using CD2 Mouse Monoclonal Antibody (UMCD2).

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Flow Cytometric Analysis of MOLT4 cells using CD2 Mouse Monoclonal Antibody (UMCD2); followed by goat anti-mouse IgG-CF488 (Blue); Isotype Control (Red).

Product Details

Synonyms

Erythrocyte receptor; LFA-2; LFA-3 receptor; Ly-37; Lymphocyte function antigen 2; Rosette receptor; SRBC; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T11

Positive Control

MOLT-4 or 293T or Jurkat cells. Lymph node and tonsil.

Known Applications & Suggested Dilutions

Func., Flow Cyt, IF, Western Blot         More Details

Functional Studies (Order Ab without Azide)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Western Blot (2-4ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human Thymocytes/Sezary T cells

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

50kDa

Specificity & Comments

CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 342-352.
  2. K.F. Kozarsky, et al, (1993) Cell Immunol 150: 235-246.
  3. G.M. Bell J.B. Imboden, (1995) J Immunol 155: 2805-2807.

Bioinformatics

  •  Entrez Gene ID: 914
  •  Gene Symbol: CD2
  •  SwissProt: P06729
  •  Chromosome Location: 1p13.1
  •  Unigene: 523500
NBT00201