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Home >> Antibodies >> CD2 / Lymphocyte Function Antigen 2 (LFA-2)

CD2 / Lymphocyte Function Antigen 2 (LFA-2)

Mouse Monoclonal Antibody [Clone BH1]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

459.00

Formulation

Purified Ab Conjugated to CF488

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab Conjugated to CF488

Price (USD)

459.00

Product Details

Synonyms

Erythrocyte receptor; Ly-37; Lymphocyte function antigen 2 (LFA-2); LFA-3 receptor; Rosette receptor; SRBC; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T11

Positive Control

293T or Jurkat cells. Lymph node and tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry: 5ul per test per one million cells (or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)Optimal dilution for a specific application should be determined.

Immunogen

Human CD2 protein

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

50kDa

Specificity & Comments

CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.

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Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Key References

  1. Wang MY et. al. An effective immuno-magnetic method for bone marrow purging in T cell malignancies. Bone Marrow Transplant. 1992;9(5):319-23.

Bioinformatics

  •  Entrez Gene ID: 914
  •  SwissProt: P06729
  •  Chromosome Location: 1p13.1
  •  Unigene: 523500
NBT00320