SDS-PAGE Analysis Purified CD147 Mouse Monoclonal Antibody (BSG/7955). Confirmation of Integrity and Purity of Antibody.
Formalin-fixed, paraffin-embedded human placenta stained with CD147 Mouse Monoclonal Antibody (BSG/7955) at 2ug/ml. Inset: PBS instead of primary antibody; secondary only negative control.
Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with CD147 Mouse Monoclonal Antibody (BSG/7955) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
This MAb recognizes extracellular epitope 2 within the N-terminal Ig domain of human CD147. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes are important factors in cancer invasion and metastasis.