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Home >> Antibodies >> CD10 (Membrane Metalloendopeptidase)

CD10 (Membrane Metalloendopeptidase)

Mouse Monoclonal Antibody [Clone CB-CALLA]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Flow Cytometric Analysis of Ramos cells using CD10 Mouse Monoclonal Antibody (CB-CALLA) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).

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Immunofluorescence staining of Ramos cells using CD10 Mouse Monoclonal Antibody (CB-CALLA) followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei were stained with Reddot.

Product Details

Synonyms

Atriopeptidase; Common acute lymphocytic leukemia antigen (CALLA); Enkephalinase (EPN); gp100; Membrane metalloendopeptidase (MME); Neprilysin; Neutral endopeptidase (NEP); Skin fibroblast elastase (SFE)

Positive Control

Ramos cells. Tonsil, small intestine or kidney (IHC).

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human CD10

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

100kDa

Specificity & Comments

Recognizes a 100kDa glycoprotein, identified as CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA). It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Guerin S; et al. Cellular Immunology, 1997 Jan 10, 175(1):85-91.
  2. Guerin S; et al. Faseb Journal, 1997 Apr, 11(5):376-81.

Bioinformatics

  •  Entrez Gene ID: 4311
  •  Gene Symbol: MME
  •  SwissProt: P08473
  •  Chromosome Location: 3q25.2
  •  Unigene: 307734
NBT00146