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Home >> Antibodies >> CD10 (Membrane Metalloendopeptidase)

CD10 (Membrane Metalloendopeptidase)

Mouse Monoclonal Antibody [Clone 56C6]

Catalog #

Size

0.1 ml
0.5 ml

Price (USD)

199.00
429

Formulation

Culture Supernatant
Culture Supernatant

Catalog No

Size

0.1 ml
0.5 ml

Formulation

Culture Supernatant
Culture Supernatant

Price (USD)

199.00
429
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Formalin-fixed, paraffin-embedded human Kidney stained with CD10 Mouse Monoclonal Antibody (56C6).

Product Details

Synonyms

Atriopeptidase; Common acute lymphocytic leukemia antigen (CALLA); Enkephalinase (EPN); gp100; Membrane metalloendopeptidase (MME); Neprilysin; Neutral endopeptidase (NEP); Skin fibroblast elastase (SFE)

Positive Control

Tonsil, small intestine or kidney (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1:50-1:100 for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human CD10 protein fragment

Cellular Localization

Cell Surface and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

100kDa

Specificity & Comments

Recognizes a 100kDa glycoprotein, identified as CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA). It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.

Related Products



Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format.

Key References

  1. Suzuko Moritani, Ryoji Kushima, Hiroyuki Sugihara, Masamichi Bamba, Tadao K Kobayashi and Takanori Hattori. Availability of CD10 Immunohistochemistry as a Marker of Breast Myoepithelial Cells on Paraffin Sections. Mod Pathol 2002;15(4):397-405.

Bioinformatics

  •  Entrez Gene ID: 4311
  •  Gene Symbol: MME
  •  SwissProt: P08473
  •  Chromosome Location: 3q25.2
  •  Unigene: 307734
NBT01697