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Home >> Antibodies >> Cathepsin D (Tumor Marker)

Cathepsin D (Tumor Marker)

Mouse Monoclonal Antibody [Clone CTSD/3082]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human liver stained with Cathepsin D Mouse Monoclonal Antibody (CTSD/3082).

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Formalin-fixed, paraffin-embedded human liver stained with Cathepsin D Mouse Monoclonal Antibody (CTSD/3082).

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Formalin-fixed, paraffin-embedded human liver carcinoma and macrophages stained with Cathepsin D Mouse Monoclonal Antibody (CTSD/3082).

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SDS-PAGE Analysis Purified Cathepsin D Mouse Monoclonal Antibody (CTSD/3082). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Cathepsin D Mouse Monoclonal Antibody (CTSD/3082)

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Western Blot Analysis of human liver tissue lysate using Cathepsin D Mouse Monoclonal Antibody (CTSD/3082).

Product Details

Synonyms

CatD; Cathepsin D; Ceroid lipofuscinosis neuronal 10; CLN10; CPSD; Epididymis secretory sperm binding protein Li 130P; Lysosomal aspartyl peptidase; Lysosomal aspartyl protease

Positive Control

K-562, A431 or SK-BR3 cells. Human kidney, liver, lung or breast tissue

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human Cathepsin D protein (around aa 104-250) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

48kDa (Procathepsin D); 34kDa (Cathepsin D); 14kDa (Cathepsin D)

Specificity & Comments

Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest. 2005 Feb;52(1-2):1-9.

Bioinformatics

  •  Entrez Gene ID: 1509
  •  Gene Symbol: CTSD
  •  SwissProt: P07339
  •  Chromosome Location: 11p15.5
  •  Unigene: 654447
NBT03082