2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603

Home >> Antibodies >> Carcinoembryonic Antigen (CEA) / CD66

Carcinoembryonic Antigen (CEA) / CD66

Mouse Monoclonal Antibody [Clone C66/1009]

Catalog #

Size

0.5 ml at 100ug/ml

Price (USD)

429.00

Formulation

Purified Ab conjugated to CF488

Catalog No

Size

0.5 ml at 100ug/ml

Formulation

Purified Ab conjugated to CF488

Price (USD)

429.00

Product Details

Synonyms

Carcinoembryonic Antigen-related Cell Adhesion Molecule 5, CEACAM5, CD66, Biliary Glycoprotein (BGP-1)

Positive Control

MCF7 or 293T cells. Colon carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood)
Immunofluorescence (1:50-1:100)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CEA protein

Cellular Localization

Cytoplasmic and luminal surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

80-200kDa

Specificity & Comments

This antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb does not react with nonspecific cross-reacting antigen (NCA) and with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.

Related Products



Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Key References

  1. Siler K, et. al. Biotechnology Therapeutics, 1993, 4(3-4):163-81.
  2. Muraro R, et. al. Cancer Research, 1985, 45:5769-80.
  3. Robbins PF, et. al. International Journal of Cancer, 1993, 53(6):892-7.
  4. Shi ZR, et. al. Journal of Histochemistry and Cytochemistry, 1994, 42(9):1215-9.

Bioinformatics

  •  Entrez Gene ID: 1048, 634
  •  Gene Symbol: CEACAM1 & CEACAM5
  •  SwissProt: P06731
  •  Chromosome Location: 19q13.1-19q13.2
  •  Unigene: 709196
NBT01009