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Home >> Antibodies >> Carbonic Anhydrase VIII

Carbonic Anhydrase VIII

Mouse Monoclonal Antibody [Clone CPTC-CA8-2]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Cerebellum stained with CA8 Mouse Monoclonal Antibody (CPTC-CA8-2).

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Formalin-fixed, paraffin-embedded human Cerebellum stained with CA8 Mouse Monoclonal Antibody (CPTC-CA8-2).

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Formalin-fixed, paraffin-embedded human Cerebellum stained with CA8 Mouse Monoclonal Antibody (CPTC-CA8-2).

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Formalin-fixed, paraffin-embedded human Cerebellum stained with CA8 Mouse Monoclonal Antibody (CPTC-CA8-2).

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SDS-PAGE Analysis Purified CA8 Mouse Monoclonal Antibody (CPTC-CA8-2). Confirmation of Purity and Integrity of Antibody

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Western Blot Analysis of K-562 cell lysate using CA8 Mouse Monoclonal Antibody (CPTC-CA8-2).

Product Details

Synonyms

CA-VIII; CALS; CARP; MGC120502; MGC99509

Positive Control

Human cerebellum. Selective expression in purkinje cells. HEK-293 and K-562 cell lines.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CA8 protein

Cellular Localization

Cytoplasmic and Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

32.97kDa

Specificity & Comments

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Shimobayashi, E, et al. Molecular Neurobiology., U.S. National Library of Medicine, Oct. 2016.

Bioinformatics

  •  Entrez Gene ID: 767
  •  Gene Symbol: CA8
  •  SwissProt: P35219
  •  Chromosome Location: 8q12.1
  •  Unigene: 654388
NBT02232