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SDS-PAGE Analysis Purified h-CALD Rabbit Recombinant Monoclonal Antibody (CALD1/7024R). Confirmation of Integrity and Purity of Antibody.
Western blot analysis of human ovary tissue lysate using h-CALD Rabbit Recombinant Monoclonal Antibody (CALD1/7024R).
Formalin-fixed, paraffin-embedded human colon stained with h-CALD Rabbit Recombinant Monoclonal Antibody (CALD1/7024R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Formalin-fixed, paraffin-embedded human colon stained with h-CALD Rabbit Recombinant Monoclonal Antibody (CALD1/7024R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120-150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70-80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This MAb recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.
Key References
