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Home >> Antibodies >> Beta-2 Microglobulin (Renal Failure & Tumor Marker)

Beta-2 Microglobulin (Renal Failure & Tumor Marker)

Mouse Monoclonal Antibody [Clone SPM374]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00

Product Details

Synonyms

B2M; Beta 2 microglobin; Beta 2 microglobulin; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; Hdcma22p

Positive Control

HL-60 or HeLa cells. Melanomas and Lymphoma. Carcinoma of Stomach, Cervix, Endometrial, Kidney or Colon.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Human PBL's from a T-cell acute lymphoblastic leukemia (T-ALL) patient

Cellular Localization

Cell Surface and Extracellular (Secreted)

Species Reactivity

Human. Does not react with Non-Human primates.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

12kDa

Specificity & Comments

Recognizes a protein of 12kDa, identified as microglobulin. Beta-microglobulin non-covalently associates with the 44kDa chain to form the HLA Class I antigen complex. Human eta-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. This MAb is specific to human microglobulin and does not react with non-human primate cells. This antibody reacts with all cell types excluding erythrocytes. The detection of 2microglobulin in body fluids has been used as a tumor marker and for monitoring patients with HIV infection.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Sparrow RL. Human cell surface antigens defined by monoclonal antibodies. PhD thesis, University of Melbourne, 1983.
  2. Brodsky FM, Parham P. Barnstable CJ, Crumpton MJ, Bodmer WF: Monoclonal antibodies for analysis of the HLA system. lmmunol Rev 47:3, (1979).
  3. Betts RL, McKenzie IFC: Monoclonal antibodies to the major histocompatibility antigens. Monoclonal hybridoma antibodies: Techniques and applications. Edited by D. Hurrel. Uniscience series program. C.R.C. Press, Cleveland, OH: 1983, pp. 193-222
  4. Leah J. Cosgrove et al.: HLA (Class I) antigens on platelets are involved in platelet function. Immunol. Cell Biol., 66 (1) 69-77 (1988)

Bioinformatics

  •  Entrez Gene ID: 567
  •  Gene Symbol: B2M
  •  SwissProt: P61769
  •  Chromosome Location: 15q21-q22.2
  •  Unigene: 534255
NBT01039