Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 12kDa, identified as microglobulin. Beta-microglobulin non-covalently associates with the 44kDa chain to form the HLA Class I antigen complex. Human eta-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. This MAb is specific to human microglobulin and does not react with non-human primate cells. This antibody reacts with all cell types excluding erythrocytes. The detection of 2microglobulin in body fluids has been used as a tumor marker and for monitoring patients with HIV infection.