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Home >> Antibodies >> BAP1 (BRCA1 Associated Protein 1)

BAP1 (BRCA1 Associated Protein 1)

Mouse Monoclonal Antibody [Clone BAP1/2667]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified BAP1 Mouse Monoclonal Antibody (BAP1/2667). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using BAP1 Mouse Monoclonal Antibody (BAP1/2667).

Product Details

Synonyms

BAP1; BRCA1 associated protein 1; Cerebral protein 13; Cerebral protein 6; HUCEP 13; Hucep 6; HUCEP13; Hucep6; TPDS; Ubiquitin carboxy terminal hydrolase; Ubiquitin carboxyl terminal hydrolase BAP1; UCHL2

Positive Control

Jurkat or PC-3 or HepG2 cells. Testis, Placenta, Ovarian or Breast Carcinoma.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human BAP1 protein fragment (around aa 191-326) (exact sequence is proprietary)

Cellular Localization

Nuclear and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

91kDa

Specificity & Comments

The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Thway K, et al. Am J Surg Pathol. 2012 Mar;36(3):462-9.

Bioinformatics

  •  Entrez Gene ID: 8314
  •  Gene Symbol: BAP1
  •  SwissProt: Q92560
  •  Chromosome Location: 3p21.1
  •  Unigene: 106674
NBT02667