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Home >> Antibodies >> Arginase 1 (Hepatocellular Carcinoma Marker)

Arginase 1 (Hepatocellular Carcinoma Marker)

Mouse Monoclonal Antibody [Clone ARG1/1126]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with ARG1-Monospecific Mouse Monoclonal Antibody (ARG1/1126).

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SDS-PAGE Analysis Purified ARG1-Monospecific Mouse Monoclonal Antibody (ARG1/1126). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using ARG1-Monospecific Mouse Monoclonal Antibody (ARG1/1126).

Product Details

Synonyms

Arginase 1; ARG1; liver-type arginase; type I arginase

Positive Control

293T cells. Hepatocellular Carcinoma (HCC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa11-97) of human ARG1 protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG3, kappa

Mol. Weight of Antigen

35-38kDa

Specificity & Comments

Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Diez, A., et al. 1994. Immunological identity of the two different molecular mass constitutive subunits of liver arginase. Biol. Chem. Hoppe Seyler 375: 537-541.

Bioinformatics

  •  Entrez Gene ID: 383
  •  Gene Symbol: ARG1
  •  SwissProt: P05089
  •  Chromosome Location: 6q23
  •  Unigene: 440934
NBT01126