Home >> Antibodies >> Annexin A1 / (Hairy Cell Leukemia Marker)

Annexin A1 / (Hairy Cell Leukemia Marker)

Recombinant Rabbit Monoclonal Antibody [Clone ANXA1/6452R]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human tonsil stained with Annexin A1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R).

Formalin-fixed, paraffin-embedded human tonsil stained with Annexin A1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R).

Western Blot Analysis of A549 cell lysate using Annexin A1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R).

SDS-PAGE Analysis Purified ANXA1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human tonsil stained with Annexin A1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R).

Western Blot Analysis of A549 cell lysate using Annexin A1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R).

SDS-PAGE Analysis Purified ANXA1 Recombinant Rabbit Monoclonal Antibody (ANXA1/6452R). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

ANXA1; ANX1; Annexin-1; Chromobindin-9; LPC1; p35

Positive Control

HeLa or A549 cells. Human esophagus, placenta or prostate.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human Annexin A1 protein

Cellular Localization

Nucleus. Cytoplasm. Cell projection > cilium. Basolateral cell membrane. Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium, also found in the

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

35kDa

Specificity & Comments

The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.