Home >> Antibodies >> Annexin A1 / (Hairy Cell Leukemia Marker)

Annexin A1 / (Hairy Cell Leukemia Marker)

Mouse Monoclonal Antibody [Clone ANXA1/3728]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Product Details

Synonyms

ANXA1; ANX1; Annexin-1; Chromobindin-9; LPC1; p35

Positive Control

A431 or K562 cell lysates. Human esophagus, placenta or prostate tissues.

Known Applications & Suggested Dilutions

ELISA, Flow Cyt, IF More Details

ELISA (For coating, order antibody without BSA)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Mixture of native proteins from human bone tissues

Cellular Localization

Nuclear and Cytoplasmic

Species Reactivity

Human

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

35kDa

Specificity & Comments

The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.