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Home >> Antibodies >> Androgen Receptor (Marker of Androgen Dependence)

Androgen Receptor (Marker of Androgen Dependence)

Recombinant Rabbit Monoclonal Antibody [Clone DHTR/8698R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

Formalin-fixed, paraffin-embedded human breast carcinoma stained with Androgen Receptor Recombinant Rabbit Monoclonal Antibody (DHTR/8698R). HIER: Tris/EDTA, pH9.0, 95C/45min. 2Ab: HRP-Poly:30min. DAB:5min.

img

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor Recombinant Rabbit Monoclonal Antibody (DHTR/8698R). HIER: Tris/EDTA, pH9.0, 95C/45min. 2Ab: HRP-Poly:30min. DAB:5min.

Product Details

Synonyms

AIS; Dihydrotestosterone receptor (DHTR); HUMARA; HYSP1; Kennedy disease (KD); Nuclear receptor subfamily 3 group C member 4 (NR3C4); SMAX1; Spinal and bulbar muscular atrophy (SBMA); Testicular Feminization (TFM)

Positive Control

LNCap cells. Human testis, breast, prostate or prostate carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Synthetic peptide corresponding to residues (within aa 1-100) of human Androgen Receptor.

Cellular Localization

Nucleus.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

110kDa

Specificity & Comments

Androgen Receptor is a member of the superfamily of ligand responsive transcription regulators. The androgen receptor functions in the nucleus where it is believed to act as a transcriptional regulator mediating the action of male sex hormones. The androgen receptor has wide distribution and can be demonstrated by immunohistochemistry in several tissues including prostate, skin, and oral mucosa. Androgen receptor has been reported in a diverse range of human tumors including osteosarcoma, and in prostatic carcinoma androgen receptor expression may be of clinical relevance.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Janne OA, et al. Androgen receptor and mechanism of androgen action. Ann Med 1993; 25:83
  2. Siu MK, et al. Oncogenesis 5:e282 (2016).

Bioinformatics

  •  Entrez Gene ID: 367
  •  Gene Symbol: AR
  •  SwissProt: P10275
  •  Chromosome Location: Xq12
  •  Unigene: 496240