2 Union Square, Union City, CA 94587
contact@NeoBiotechnologies.com
510-376-5603
Catalog #
Size
Price (USD)
Formulation
Catalog No
Size
Formulation
Price (USD)
Formalin-fixed, paraffin-embedded human Tonsil stained with AMPD3 Mouse Monoclonal Antibody (AMPD3/901)
Formalin-fixed, paraffin-embedded human Placenta stained with AMPD3 Mouse Monoclonal Antibody (AMPD3/901)
SDS-PAGE Analysis Purified AMPD3 Mouse Monoclonal Antibody (AMPD3/901). Confirmation of Integrity and Purity of Antibody.
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It recognizes a protein of ~90kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 3.5.4.6. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This MAb shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This MAb is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens.
Key References
