|Catalog No||Formulation||Size||Price (USD)|
|1014-RBM2-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|1014-RBM2-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|1014-RBM2-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||1014|
|Human Gene Symbol||CDH16|
|Human Chromosome Location||16q22.1|
|Synonyms||Cadherin-16 (CDH16); Kidney-specific cadherin; Ksp-cadherin antibody|
|Immunogen||Recombinant full-length human CDH16 protein|
|Host / Ig Isotype||Rabbit / IgG|
|Mol. Weight of Antigen||130kDa|
|Cellular Localization||Cell Surface with some Cytoplasmic|
|Species Reactivity||Human, Mouse and Rat. Others not known.|
This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
Flow Cytometry (0.5-1ug/million cells)
Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA buffer, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Normal kidney or renal cell carcinoma.
200ug/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.