|Catalog No||Formulation||Size||Price (USD)|
|2492-MSM1-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|2492-MSM1-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|2492-MSM1-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||2492|
|Human Gene Symbol||FSHR|
|Human Chromosome Location||2p21-p16|
|Synonyms||Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; FSHRO; LGR1; ODG1; ovarian dysgenesis 1|
|Immunogen||Recombinant human full-length FSHR protein|
|Host / Ig Isotype||Mouse / IgG1|
|Mol. Weight of Antigen||75kDa|
|Cellular Localization||Cytoplasmic & Cell Surface|
|Species Reactivity||Human. Others not known.|
Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its and subunits. While the subunit of FSH is involved in the binding of FSH to the receptor, the subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
Flow Cytometry (0.5-1ug/million cells)
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, or 10mM Citrate buffer, pH6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.