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Home >> Antibodies >> Catenin, gamma (Cardiomyocyte Marker)

Catenin, gamma (Cardiomyocyte Marker)

Mouse Monoclonal Antibody [Clone 11 E4]

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Catalog No Formulation Size Price (USD)  
3728-MSM1-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 199.00
3728-MSM1-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 379.00
3728-MSM1-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 399.00
Human Entrez Gene ID 3728
Human SwissProt P14923
Human Unigene 514174
Human Gene Symbol JUP
Human Chromosome Location 17q21
Synonyms ARVD12; Catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; Junction Plakoglobin; PDGB; PKGB
Immunogen Recombinant full length human plakoglobin, fused to maltose binding protein
Host / Ig Isotype Mouse / IgG1, kappa
Mol. Weight of Antigen 80-87kDa
Cellular Localization Cell Surface and Cytoplasmic
Species Reactivity Human and Mouse. Others not known.

Specificity & Comments

It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (, , and ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. T-catenin binds to E-catenin as well as to -catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for -T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

Known Applications & Suggested Dilutions

Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (1-2ug/ml)
Western Blotting (0.5-1.0ug/ml)
Optimal dilution for a specific application should be determined.

Positive Control

HT20, A549, 293 or A431 cells. Skin

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


This antibody is available for research use only and is not approved for use in diagnosis.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Sacco, PA; McGranahan, TM; Wheelock, MJ; Johnson, KR. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem 1995, 270:20201-6
  2. Johnson, KR; Lewis, JE; Li, D; Wahl, J; Soler, AP; Knudsen, KA; Wheelock, MJ. P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207: 252-60