|Catalog No||Formulation||Size||Price (USD)|
|3728-MSM1-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|3728-MSM1-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|3728-MSM1-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||3728|
|Human Gene Symbol||JUP|
|Human Chromosome Location||17q21|
|Synonyms||ARVD12; Catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; Junction Plakoglobin; PDGB; PKGB|
|Immunogen||Recombinant full length human plakoglobin, fused to maltose binding protein|
|Host / Ig Isotype||Mouse / IgG1, kappa|
|Mol. Weight of Antigen||80-87kDa|
|Cellular Localization||Cell Surface and Cytoplasmic|
|Species Reactivity||Human and Mouse. Others not known.|
It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (, , and ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. T-catenin binds to E-catenin as well as to -catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for -T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
Flow Cytometry (0.5-1ug/million cells)
Western Blotting (0.5-1.0ug/ml)
Optimal dilution for a specific application should be determined.
HT20, A549, 293 or A431 cells. Skin
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.