|Catalog No||Formulation||Size||Price (USD)|
|1500-MSM1-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|1500-MSM1-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|1500-MSM1-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||1500 (Human)|
|Human SwissProt||O60716 (Human)|
|Human Unigene||166011 (Human)|
|Human Gene Symbol||CTNND1|
|Human Chromosome Location||11q11|
|Synonyms||Cadherin-associated Src substrate (CAS); Catenin (cadherin associated protein) delta 1; Catenin delta-1; CTNND1; p120 catenin; P120 CTN; p120(cas); p120(ctn); P120CAS; P120CTN|
|Immunogen||Mouse p120 Catenin (pY96)|
|Host / Ig Isotype||Mouse / IgG1, kappa|
|Mol. Weight of Antigen||120kDa|
|Cellular Localization||Cell Surface|
|Species Reactivity||Human and Rat. Others not known.|
The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
Flow Cytometry (0.5-1ug/million cells)
Optimal dilution for a specific application should be determined.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.