|Catalog No||Formulation||Size||Price (USD)|
|1495-MSM1-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|1495-MSM1-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|1495-MSM1-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||1495|
|Human Gene Symbol||CTNNA1|
|Human Chromosome Location||5q31.2|
|Synonyms||Alpha E-catenin; Cadherin-associated protein; CAP102; Catenin alpha-1; CTNNA1; Renal carcinoma antigen NY-REN-13|
|Immunogen||Human alpha catenin fusion protein|
|Host / Ig Isotype||Mouse / IgG1|
|Mol. Weight of Antigen||102kDa|
|Cellular Localization||Cell Surface|
|Species Reactivity||Human. Others not known.|
Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, -catenin forms a heterodimer with -catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.
Flow Cytometry (0.5-1ug/million cells)
Western Blotting (0.5-1.0ug/ml)
Optimal dilution for a specific application should be determined.
HeLa, A431 or MCF-7 Cells
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.