|Catalog No||Formulation||Size||Price (USD)|
|939-MSM2-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|939-MSM2-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|939-MSM2-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||939|
|Human Gene Symbol||CD27|
|Human Chromosome Location||12p13|
|Synonyms||LPFS2; S152; T cell activation antigen S152; T-cell activation antigen CD27; T14; TNFRSF7; TNFSF7; Tp55; Tumor necrosis factor receptor superfamily member 7|
|Immunogen||Recombinant human CD22 protein (exact sequence is proprietary)|
|Host / Ig Isotype||Mouse / IgG1|
|Mol. Weight of Antigen||120kDa|
|Cellular Localization||Cell Surface|
|Species Reactivity||Human. Others not-tested.|
Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27. It is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFB and SAPK/JNK and induces apoptosis.
Flow Cytometry (0.5-1ug/million cells)
Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Human peripheral blood lymphocytes. Human tonsil and lymph node.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.