|Catalog No||Formulation||Size||Price (USD)|
|3684-MSM3-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|3684-MSM3-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|3684-MSM3-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|Human Entrez Gene ID||3684 (Human)|
|Human SwissProt||P11215 (Human)|
|Human Unigene||172631 (Human)|
|Human Gene Symbol||ITGAM|
|Human Chromosome Location||16p11.2|
|Synonyms||CD11 antigen-like family member B; CD11b/CD18; CD49d; Cell surface glycoprotein MAC-1 subunit alpha; Complement Component Receptor 3 Alpha; CR3 Alpha Chain (CR3A); Integrin alpha-M; Integrin beta 2 alpha subunit; ITGAM; Leukocyte adhesion receptor MO1; Ly-40; Mac-1a; MAC1; Mac1, alpha subunit; MAC1A; Macrophage antigen alpha polypeptide; MO1A; Neutrophil adherence receptor alpha M subunit|
|Immunogen||Recombinant human ITGAM protein|
|Host / Ig Isotype||Mouse / IgG1, kappa|
|Mol. Weight of Antigen||95kDa & 170kDa|
|Cellular Localization||Cell surface|
|Species Reactivity||Human, Others not known.|
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin M combines with the Integrin 2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin M/2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b and CD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Optimal dilution for a specific application should be determined.
Human monocytes & granulocytes. Human lymph nodes and tonsils.
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. ,Antibody is stable for 24 months. Non-hazardous. No MSDS required.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.