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Home >> Antibodies >> Bcl-6 (Follicular Lymphoma Marker)

Bcl-6 (Follicular Lymphoma Marker)

Mouse Monoclonal Antibody [Clone BCL6/1526]

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Catalog No Formulation Size Price (USD)  
604-MSM6-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 199.00
604-MSM6-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 379.00
604-MSM6-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 399.00
Human Entrez Gene ID 604
Human SwissProt P41182
Human Unigene 478588
Human Gene Symbol BCL6
Human Chromosome Location 3q27.3
Synonyms B-cell lymphoma 5 protein; B-Cell Lymphoma 6 Protein; BCL5; BCL6; BCL6A; cys his2 zinc finger transcription factor; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S
Immunogen Recombinant human bcl-6 protein fragment (aa256-389) (exact sequence is proprietary)
Host / Ig Isotype Mouse / IgG1
Mol. Weight of Antigen 95kDa
Cellular Localization Nuclear
Species Reactivity Human. Others not known.

Specificity & Comments

Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( L&H ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

Known Applications & Suggested Dilutions

Flow Cytometry (0.5-1ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Positive Control

Raji or Ramos cells. Tonsil or Hodgkin s lymphoma.

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


This antibody is available for research use only and is not approved for use in diagnosis.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Garcia JF, et al. 2006. J. Histochem Cytochem. 54:31.
  2. Pasqualucci, L., et al. 2003. Leuk. Lymphoma 44 Suppl 3: S5-12.
  3. Ree, H.J., et al. 2003. Hum. Pathol. 34: 610-616.